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Exhibit 3 Projected United States Population Aged 50+ (M) Source: US Census Bureau The chronic disease burden further supports this outlook

(2017) 114:E6566e75

This paper identifies these obstacles and offers actionable strategies, such as leveraging public-private partnerships, integrating flexible financing models, and promoting community-led planning frameworks

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One patient with severe knee and shoulder instability, for instance, received prolotherapy a few times per year over more than a decade and was able to continue working and stay active without recurrent dislocations

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