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Additionally, defective de novo NAD + synthesis has also demonstrated to be a contributing factor in the decrease of renal NAD + levels, especially in the context of renal IRI, which causes a reduction in the expression of de novo NAD + biosynthetic enzymes and the accumulation of certain intermediates, such as quinolinate [146, 147]

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Astrocytes and amyotrophic lateral sclerosis/motor neuron diseases Motor neurons are damaged by oxidative stress and reactive astrogliosis in ALS patients (Rao and Weiss, 2004

, 9 on the other hand, found no differences in the activities of CuZn-SOD, CAT and GPx between SHR and age-matched 6-month-old WKY rats, but found some discordance in Mn-SOD, CuZn-SOD, CAT and GPx protein levels in the medulla and cortex of SHR