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The increased methylation capacity of cells, provided by higher concentrations of SAM, would lead to the hypermethylation of regulatory regions of pro-inflammatory genes attenuating inflammation

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A recent systematic review and meta-analysis highlighted the high global prevalence of diabetic foot ulceration among DPN patients, emphasizing the critical need for early detection and comprehensive management strategies to prevent severe outcomes

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[2] Second, in cultured dermal microvascular and fibroblast models, GHK-Cu exposure has been associated with increased vascular endothelial growth factor expression, a change that could enhance perifollicular microcirculation