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In addition, GLP-1 expression was down-regulated in wild-type Lox5 cells knocked out by FNDC5, and the induced expressions of lipolysis and autophagy-related genes and proteins were also inhibited, such as ATGL, HSL, and hepatic lipase deficiency gene (LIPC), suggesting that GLP-1 expression is also regulated by FNDC5, and may also provide therapeutic targets for lipid metabolism-related diseases

The correlation between the clinical features collected for each study groups was studied using the Spearmans rank correlation analysis

The scRNA-seq results showed that the expression of YAP/TAZ target genes, which play a central role in mechano-stress responses, was upregulated in LSECs in the pIVCL group, and that connective tissue growth factor (CTGF) was the most greatly upregulated gene in the whole LSEC population and more upregulated in zone 3 LSECs than in zone 1 LSECs

Abstract Metabolic syndrome (MS) is a prominent cause of death worldwide, posing a threat to the global economy and public health

doi: 10.1002/tox.23832 79 WangXXuSZhangLChengXYuHBaoJet al

By reducing oxidative stress, glutathione lowers the risk of cancer development