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Toxins, on the other hand, could be either exogenous (found in the environment) or endogenous (produced by the body)

J Consult Clin Psychol 64:295304

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Notably, in breast cancer, BMS-777607 (a RON tyrosine kinase inhibitor) can increase resistance to cytotoxic chemotherapy drugs, including Dox (31)

For example, BDE-47 causes increased mortality, a decreased proportion of granulosa cells, decreased phagocytic activity, increased lysosomal membrane permeability, and changes in the activity of the antioxidant system and oxidative stress in Ruditapes philippinarum and Mytilus edulis (Zhou and Liu, 2022)

In fact, NRF2 deletion causes an increase in OS and cellular death both in vitro and in vivo [137, 138]