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10.3389/fendo.2025.1618984 94 WangX.HuangY.YangY.TianX.JinY.JiangW.et al (2025)

Comparative evaluation of these analogs alongside DJX-A-KM at a lower concentration (20 nM) revealed that both increases and decreases in electrophilicity compromised KRAS G12C degradation efficiency to varying degrees, with DJX-A-KM remaining the most potent, achieving ~80% degradation (Fig