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122 The authors concluded that NAC may improve markers of inflammation or oxidation, systemic oxygenation, the need for/duration of ventilation, rate of patient recovery and clinical improvement score, whilst effects on length of stay, CT/x-ray images, mortality rate and pulmonary complications were inconclusive

Germ-free (GF) mice exhibit lower levels of IGF-1 in the liver compared to conventionally raised mice [14]

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In the present review, we will focus mainly on the signaling cascade of TLR4 because it is believed to be the main sensor of bacterial LPS (Ignacio et al., 2016)

With regard to the TGF--mediated EMT pathway, several studies have mentioned that the pro-inflammatory cytokines IL-6, IL-17, and IL-22, which share this pathway, are also involved in the fibrotic mechanism of SG (53, 55, 57)

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