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Clinical studies examining oxidative stress biomarkers in individuals with migraine have found that the number of monthly headache days was negatively correlated with serum concentrations of two antioxidant enzymes, catalase and superoxide dismutase, and total antioxidant capacity while being positively correlated with serum levels of glutathione peroxidase 1, nitric oxide, and malondialdehyde (3739)

Among the most effective candidates are transferrin receptor ligands, lactoferrin, Angiopep-2, apolipoproteins, and glutathione-based systems

D5R expressed on DCs plays a role in MS by regulating Th1 and Th17 differentiation, T cell functions, and GM-CSF-producing CD4+T cells via STAT3/NF-B/IL-6/12/23 pathway, and is correlated with disease severity (155)