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A butenolide derivative from Streptomyces koyangensis SCSIO 5802 exhibits anti-HSV-1 activity (EC 50 = 25.4 M), while compounds from Simplicillium obclavatum EIODSF 020, including simplicilliumtide J and verlamelins A and B, inhibit HSV-1 with IC 50 values of 14.016.7 M [130]

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