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In mammals, H 2 S elicits a biphasic, concentration-dependent mitochondrial response 14 , which can be cytotoxic or cytoprotective

After centrifugation at 10,000 g for 5 min at 4 C, the supernatant containing cytosolic proteins was collected, and the pellet was washed with resuspension buffer

3 Increased expression of the receptor for AGEs (RAGE) and its activating ligands