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In wounded tissue, nociceptive signaling is not merely a consequence of direct activation of peripheral nerves by trauma but arises from a dynamic interplay between immune, inflammatory, and neural components of the tissue microenvironment

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Collectively, these data demonstrate that full-length LION/repRNA gH/gL elicits a qualitatively different antibody response than the LION/repRNA gH/gL ectodomain, resulting in higher neutralizing titers

Once B12 levels are stabilised, the frequency typically reduces to every 2-3 months, although the exact frequency should be prescribed by a healthcare provider

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