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Metabolomics and lipidomics was performed and analysed by Metabolomics Platform from University of Chicago Medicine Comprehensive Cancer Center (RRID: SCR_022932) supported by H

Nuclear folate metabolism

Filters were vortexed with 650L sterile AE buffer for one minute and centrifuged briefly

F.LangbehnD.LoK.LeavittB

Therefore, to meet practical demands, the rational design of AIE phototheranostic systems and manipulating their absorbed photon energy dissipation for generating fluorescence for imaging, ROS for PDT and heat for PAI/PTT according to practical demand are important and will be discussed