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Yeim et al

There is a point of view that understanding mechanisms is not as important as exploring the functional aspects of a phenomenon: we can remain agnostic about mechanism while we investigate and describe function, on the understanding that we will fill in the gaps in our understanding at some later point

2005 Jul

86 Combining lactulose with PEG might be helpful, which was assessed in a non-inferiority trial that randomized 40 patients with cirrhosis and HE to receive either lactulose alone (2030 g orally or 200 g enema) or a similar dose of lactulose plus PEG (280 g in 4 L of water orally as a single dose in 30120 m)

PL-PUFA, phospholipid containing polyunsaturated fatty acid chain

Increased nuclear REST resulted directly decreasing the levels of miR-132 and miR-124a and indirectly via inhibition of BDNF expression consequently leading to inhibition of neurite outgrowth [69]