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The measurements were performed with a CytoFlex flow cytometer (Beckman Coulter Inc, Brea, California, USA) using the CytExpert program

NLRP3 NLR, family pyrin domaincontaining 3

Melatonin protects the electron transport chain (ETC) by binding to the Fe-S cluster of NADPH dehydrogenase, reducing the generation of superoxide anion radicals (O2) caused by electron leakage, blocking the opening of the mitochondrial permeability transition pore (mPTP), and preventing apoptosis caused by cytochrome C leakage (Hardeland, 2017

The major clinical symptoms include dementia, apathy, social withdrawal, mood swings, depression, disturbed sleep, and delusions

Pralsetinib Pralsetinib is an oral RET-targeted therapy

J Neurochem 78:10731082 Tseng H-C, Wang M-H, Chang K-C, Soung H-S, Fang C-H, Lin Y-W, Li K-Y, Yang C-C, Tsai C-C (2020) Protective effect of () epigallocatechin-3-gallate on rotenone-induced parkinsonism-like symptoms in rats