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Pretreatment with the GlyT1 inhibitors, sarcosine (competitive) and NFPS/ALX5407 (non-competitive), has been shown to promote neuroprotection in both ex vivo oxygenglucose deprivation (OGD) models and in vivo global cerebral ischemia models (Pinto et al

doi: 10.3390/ijms21207452 26 PeronRVatanabeIPManzinePRCaminsACominettiMR

Effects of ACR and MEL on brain tissue histopathology Histopathological examination of the rat brain at the end of the experiment revealed distinct findings across the experimental groups