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This interaction triggers c-Met phosphorylation and activates downstream signaling cascades including the PI3K/AKT and MAPK/ERK pathways, which are fundamental to neuronal survival, dendritic arborization, and synapse formation

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Alamandine attenuates sepsis-associated cardiac dysfunction via inhibiting MAPKs signaling pathways

However, no research directly compares continuous use versus cycling protocols (such as 12 weeks on, 4-8 weeks off), leaving optimal long-term strategies somewhat uncertain

weeks 34 , noticeable functional improvement (better range of motion, less morning stiffness)