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With an increase in oxidative stress, Nrf2 is released and translocates to the nucleus, where it binds and activates the ARE and upregulates several genes associated with glutathione synthesis and antioxidant defense (Figure 2) [45,48]

Characterization of iPSC derived from Control and CLN3 patient fibroblasts

Radioimmunoassay for glutamic acid decarboxylase (GAD65) autoantibodies as a diagnostic aid for stiff-man syndrome and a correlate of susceptibility to type 1 diabetes mellitus