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Key Takeaways: Theres not much research on B12 shots for weight loss

But it failed to demonstrate significant weight loss in six clinical trials, and its development was terminated because of those failures

Begin with 250mcg daily for the first week to assess tolerance

People exposed to nitrous oxide (medical or recreational use) may develop functional B12 deficiency, as the gas inactivates B12-dependent enzymes, potentially requiring supplementation

Therapeutic doses of vitamin D can differ based on the same variables, but 50,000 IU (1,250 mcg) is a common amount according to the journal Nutrients