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Progress in Neuro-Psychopharmacology and Biological Psychiatry

Additionally, the glutathione S-transferase alpha 3 gene, GSTA3 , contained a hypermethylated CpG site in TI heifers and has been shown to increase ROS production when knocked down in cell culture [72]

In addition, as mitochondrial diseases particularly affect tissues and cells that are highly dependent on mitochondrial energy production (such as neuronal, muscle and cardiac cells) (Pfeffer et al., 2013), the use of brain organoids to study the role of mitochondria in neurodevelopmental disorders is a revolutionary strategy