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These findings highlight the inherent liabilities in current approaches used to inhibit AR action in PCa and are instructive as to strategies that can be used to develop new therapeutics for this disease and other androgenopathies

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Its downregulation has been shown to suppress the degradation of unsaturated fatty acids through multiple mechanisms, including inhibiting the activity of key enzymes involved in fatty acid catabolism (e.g., acetyl-CoA dehydrogenase, lipoxygenase, and fatty acid dioxygenase) and activating the PPAR signaling pathway and its downstream target genes [71]

doi: 10.1126/science.1224631 89

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