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Additionally, piperacillin-tazobactam is a substrate for OAT1 and OAT3, competitively decreasing tubular secretion of creatinine, and causing pseudo-toxicity due to rising serum creatinine levels without tubular damage

10 These detailed studies further highlight the complexity of the mucosal barrier properties and reveal that alterations in cytoskeletal proteins and TJ-integral and -associated proteins can affect mucosal permeability as well as epithelial cell homeostasis