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doi: 10.14336/AD.2021.0302 [PubMed] 34300194 Alolayan YS, McKinley K, Bhatia R, Alkhachroum A

The Billon 2025 paper (PMID 41421047) is the citation that anchors the route question: SLU-PP-915 was developed because SLU-PP-332 "lacks oral bioavailability." If the parent compound does not absorb orally, oral capsules and tablets are unlikely to produce the systemic ERR agonism seen in mice