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In the case of the JNK inhibitor SP600125, which is only soluble in DMSO and requires early treatment, 70% of the protection against APAP toxicity was caused by DMSO and 30% by SP600125 [36]

IGF-1 has also increased the -secretase processing of endogenous APP and the ectodomain shedding of APP and APP-like proteins 1 and 2 in SH-SY5Y cells [186, 187]

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