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Trials conducted between 2001 and 2007 demonstrated statistically significant reductions in body fat, although the larger Phase IIb OPTIONS trial did not replicate these findings at sufficient magnitude for regulatory approval, and formal development was discontinued in 2007

All participants signed an informed consent form

This neuroendocrine pathway is mechanistically distinct from the hypothalamic and gut-brain circuits predominantly engaged by GLP-1 receptor agonists

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B12 is non-toxic and there is no known upper limit

The injectable form ensures rapid delivery into the bloodstream for effective absorption