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IAP significantly inhibited the migration of HT-29 cells at 48 and 72 h compared with that of the control group

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10.1038/onc.2008.188 87 RheeS

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At the periphery, the production of neopterin and nitric oxide during inflammation consumes tetrahydrobiopterin to the detriment of the hydroxylase enzymes that use this compound as a cofactor.[ref] Genetic variants can also significantly influence BH4 levels when the body is under stress

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