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Although the overall number (frequency) of Tregs may be unchanged in MS patients compared to controls, studies indicate that their inhibitory function is impaired, which correlates with diminished immune control in vivo (Costantino et al., 2008)

These discoveries gain additional significance in light of recent evidence linking ferroptosis induction to enhanced immunotherapy efficacy, where GSH depletion-triggered ferroptosis can boost anti-tumor immunity through promoting the maturation of dendritic cells and the priming of CD8 + T cells [36]

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Teratology and a perinatal and postnatal toxicity study in rats were performed with a combination of acetylcysteine solution and isoproterenol administered by the inhalation route