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Mitochondria as central hubs in synaptic modulation

In summary, by integrating high-content single-cell level imaging analyses with mechanistic studies, extensive preclinical therapeutic experiments and a Phase Ib clinical trial, our studies herein elucidate the AR +/- BCL-2 +/- PCa cell subpopulation dynamics and credentials BCL-2 as a vital therapeutic target in heterogeneous CRPC

By comparing an AGE-directed strategy with antioxidant repletion, this study aims to clarify whether targeting AGE-related molecular damage provides benefit beyond general redox support in the context of diet-associated reproductive dysfunction

I then sanded the pieces reasonably smooth with 800 grit sand paper

The main goal of 3D cultures is to provide cells with a bulk ECM with properties that guide cells to develop or sustain a desired phenotype and, implicitly, to rely upon the cells themselves to create a local 3D microenvironment that mimics the in vivo microenvironment

The rates of complete recovery increase with early use of a corticosteroid