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Description

Tetrandrine alleviates symptoms of rheumatoid arthritis in rats by regulating the expression of cyclooxygenase-2 and inflammatory factors

We utilized RNA sequencing, bioinformatic approaches, and both in vivo and in vitro experiments to confirm that TMAO promotes cholelithiasis by dysregulating hepatic cholesterol metabolism through its effects on the key regulatory genes apolipoprotein A4 ( APOA4) and proprotein convertase subtilisin/kexin type 9 ( PCSK9 )