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It is a substrate for -ketoglutarate dehydrogenase (OGDH) in oxidative reactions generating succinyl-CoA and isocitrate dehydrogenase 1 (IDH1) or isocitrate dehydrogenase 2 (IDH2), which catalyze the reductive carboxylation reaction converting -KG to isocitrate

The regulatory role of the vascular endothelium in maintaining cardiovascular health is widely recognized in scientific literature

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There are other alkylating agents used earlier for masking GSH in glutathione assay like N-ethyl-maleimide, 2-Vinylpyride etc

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