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Datopotamab deruxtecan: a novel antibody drug conjugate for triple-negative breast cancer

Natural compounds like midazolam, vitamin B12, metformin, Cangrelor, and hesperidin have also shown anti-inflammatory effects in preclinical MIRI models, often by modulating macrophage polarization or inhibiting inflammatory pathways like NF-B (Huang et al., 2020

Heme Heme is a DAMP released from red blood cells, whose excessive release due to hemolysis is a key feature of several disease states, including sepsis, malaria, and sickle cell disease

The underlying mechanism of microglial activation induced by METH is related to the Toll-like receptor 4 (TLR4) located on microglia, which is involved in the immune surveillance of pathogens and exogenous small molecules (Bachtell et al., 2015)

Zhang Y, Sturgis EM, Zafereo ME , Wei Q, Li G

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles