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Another challenge to overcome for the next-generation nanomedicines resides in the regulatory classification, because the lack of knowledge regarding biosafety and long-term effects of nanomaterials leads to a regulatory uncertainty and deficient standards and protocols for scale-up manufacturing and safe clinical uses [678,679]

10.15420/ecr.2019.17.2 198 ShreeP.MishraP.SelvarajC.SinghS

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Mittal et al., 2014)

Mice with apolipoprotein E deficiency and knocked down NF-B p50 showed higher serum levels of TNF-, IL-6, and cholesterol and more pronounced atherosclerotic lesions than mice with apolipoprotein E deficiency alone ( Upstream of NF-B has also been discussed in the IH-mediated AS

High glucose-induced accumulation of persistent peroxidation in cardiomyocytes triggers ferroptosis and results in cell damage in H9C2 cells and New Zealand rabbits