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Some of the proposed pathophysiological mechanisms that have been proposed to account for the relationship between UPF, as well as the risk of mood disorders such as depression, include genetically based factors, including the MC4R gene, CRY1 gene, and Cav1 gene, which are associated with an elevated risk of developing depression (60)

NRF2 is reported to have suppressive effects on the lipogenic pathway via inhibiting the activity of LXR 64,70 , a transcription factor that supports lipid synthesis

doi: 10.1016/j.nut.2025.112800 [DOI] [PubMed] [Google Scholar] 96.Yuan S, Zhu T, Gu J, Hua L, Sun J, Deng X, et al

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