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Under specific conditions, astrocytes can also release neurotransmitters like D-serine into the synaptic cleft, thereby regulating the function of neuronal N-methyl-D-aspartate (NMDA) receptors and influencing the strength and direction of neurotransmission (Sacks et al., 2018)

Future research should intensify preclinical toxicity studies on PT saponin components

336 Several underlying factors, such as differences in the experimental design, model systems, or patient heterogeneity, may account for the differences in the mechanisms of action of CP31398 and APR-246 and cause different therapeutic responses

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This included Israel Simon Kleiner and Samuel Meltzer, two American physiologists, based at the Rockefeller University in New York who in 1915 demonstrated with animal experiments the power of intravenously administered pancreatic extracts in lowering blood sugar