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Patients were asked to report the extent to which each of their selected symptoms was impacted by each treatment, again selecting from seven options (e.g., much better, slightly worse, et al.) To investigate the effects of the top 20 treatment groups on these five core symptoms, we calculated symptom-specific NASs, which then were compared to the NAS for the reference, vitamin C, to determine which were significantly different ( SI Appendix , Table S4)

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Genome-wide DNA methylation profiles and small noncoding RNA signatures in sperm with a high DNA fragmentation index

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Finally, we performed sensitivity analyses by iteratively removing each study and reestimating the overall outcomes