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Another significant source of external oxidative stress is exposure to heat and radiation

These include infection or irregular lumps on the penis or even possibly erectile dysfunction

Cancer Cell 40(9):895-900, 2022

S., & Golzar, F

Visceral hypersensitivity, serotonin dysregulation, gut-brain axis dysfunction, and central/peripheral nervous system alterations are implicated in IBS-C pain, while FC pain is less studied and may be primarily linked to colonic distension and motility dysfunction