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Although peptides are generally considered to be less immunogenic than proteins, the repeated or prolonged exposure of damaged tissue to synthetic or modified peptides can still pose a risk of local irritation, allergic response, or immune activation [268,269,270]

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In addition, NRF2 can also regulate the transcriptional expression of metabolites involved in intermediate metabolism, some of which play essential roles in the regeneration of NADPH, a key electron donor needed to reduce oxidative substrates [108]

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