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As expected, and consistent with a reduced interaction of the amidated C-terminal tyrosine with the CTR ECD, CagriP37Y presented a lower potency than Cagri in cells expressing CTR alone (Supplementary Fig

40 , D370D376 (2012)

This is among the more speculative areas of research

No interpretations extend beyond analytical research contexts, and no claims are made regarding biological outcomes, clinical relevance, or applicability outside controlled experimental systems

Each batch is independently tested by a third-party laboratory not in-house

A second cohort of mice including WT, RAMP1 KO, RAMP3 KO, and RAMP1/3 KO genotypes confirmed that both RAMP1 and RAMP3 are individually essential for a full cagrilintide-induced neuronal activation response