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Off-target senescent cell clearance Although senescent cell clearance is beneficial, some senescent cells are beneficial (e.g., during wound healing)

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Normal saline: The base of the IV is a mixture of water and electrolytes

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Moreover, the R17 Cagri- E14 Cagri ionic lock was present in the bypass conformation but absent in the CT-like conformation in both CagriBB-bound structures, consistent with a higher energy requirement to form the CT-like conformation (Supplementary Fig