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Chem Commun (Camb)

Gallogly MM, Starke DW, Mieyal JJ

doi: 10.3390/ijms23147722 91

Pathophysiology of ischemic acute kidney injury

Note that 2-PAM has an affinity for the acetylcholine anionic binding site on cholinesterase (right middle panel), which could explain the oxime related worsening of cholinergic side effects when 2-PAM is administered prior to the onset of action of atropine in the setting of organophosphate poisoning, by transiently preventing nerve-agent free cholinesterase from interacting with acetylcholine

Notably, the NOX family, the only enzymes specifically dedicated to ROS generation, plays a crucial role in the pathogenesis of DCM