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Approach Phase 2b trial arm Duration 24 weeks Review Point Week 12 and 24 Notes METAOD006 (OPTIONS) used 24 weeks at oral doses 0.25, 0.5, or 1 mg/day in 502 obese adults

Prophylactic in vivo protection was assessed by intravenous administration of WRAIR-5001 or WRAIR-5021 at a dose equivalent to 10 mg/kg, side-by-side with control mAb WRAIR-2125 34 , (positive control SARS-CoV-2 neutralizing mAb isolated from a convalescent donor), and an IgG isotype control (Zika mAb MZ4), 24 hours prior to administration of SARS-CoV-2 Delta (B.1.617.2) challenge virus (Fig

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