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The main effect is reached in about six to eight weeks from initial treatment.Long-term effects, such as skin tightening, collagen production and enhanced skin quality, may take up to three to four months to be noticed and can last from six to 12 months.

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Treatments for flushed skin can depend on the underlying cause

J Mater Chem B 2023;11:3124-35

Therefore, it would be difficult to distinguish patients with GHD from those without GHD using those parameters

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