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(NCCN) Clinical Practice Guidelines in Oncology

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Studies on sepsis mouse models have shown that up-regulation of PD-L1 can inhibit the activity of caspase-3 and up-regulate the expression of Mcl-1 through the PD-1/PI3K/Akt signaling pathway, thereby delaying neutrophil apoptosis, leading to their abnormal accumulation in the lungs and exacerbating lung injury (42)

2004;164(19):214755 Sasso FC, Pafundi PC, Marfella R, Calabr P, Piscione F, Furbatto F, Esposito G, Galiero R, Gragnano F, Rinald L, Salvatore T, DAmico M, Adinolfi LE, Sardu S

In the duodenum, the first section of the small intestine, the B12-R protein complex splits apart

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