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Giles FJ, Kantarjian HM, Kornblau SM , Thomas DA, Garcia-Manero G, Waddelow TA, David CL, Phan AT, Colburn DE, Rashid A, Estey EH

Paraptosis inducer to effectively trigger immunogenic cell death for metastatic tumor immunotherapy with IDO Inhibition

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Additionally, deficiencies of HDAC1 and HDAC2 can reduce cell survival via decreasing the acetylation status of H3K56ac, H4K16ac and H4K91 [68], suggesting the positive effects of HDAC1 and HDAC2 on cell survival

As each approach targets only one aspect of the underlying pathophysiology, a single mechanism is unlikely to achieve optimal clearance

Association study of a functional catechol-O-methyltransferase polymorphism and smoking in healthy Caucasian subjects