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Each blot was scanned densitometrically for quantitation, with each blot having its own unique Kinexus scan identification number

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The limitation of that study was the small number of patients, but the authors concluded that compared with healthy neonates, the HIE group had increased melatonin, SOD, and NO concentrations, and the combination of melatonin to therapeutic hypothermia in infants with HIE can improve neurodevelopmental outcome at 6 months of age with effective effects in reducing oxidative stress in terms of NO and SOD serum level reduction

In an ovalbumin-sensitized rat model, 4 days of oral treatment with -tocopherol diminished eosinophil infiltration in the nose, sinuses, and nasolacrimal duct but not in the lung after allergen challenge [83]

Third, adaptive clinical trial designs involving larger patient cohorts and multi-center validation will be crucial to demonstrate efficacy beyond preclinical promise

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