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To protect against radical-mediated damage, muscle cells contain endogenous antioxidants to scavenge radicals

26,27 Moreover, the iron exporter ferroportin (FPN) has also been shown to regulate cellular sensitivity to ferroptosis in vitro

The management of GBM is hampered by several challenges, including tumour heterogeneity, the presence of therapy-resistant glioma stem cells, the highly infiltrative growth pattern of tumour, primary and acquired drug resistance, and BBB, which restricts drug delivery 7,8,27,28,29

It is well-known that the gut microbiota activates the growth and development of the immune response and plays a vital role in immune cell maturation, too

E., & Maenhaut, C

Declaration of patient consent The authors certify that they have obtained written informed consent from all the patients