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Description

Animal Research Context Published preclinical studies typically use 2.5 to 10mcg per kilogram of body weight

Clinical trials test 0.16 to 4.5 mg subcutaneously once weekly (Lau 2021, Lancet)

Because angiogenesis is a defining hallmark of tumor growth and metastatic progression, any therapeutic agent that enhances neovascularization could, in theory, facilitate tumor expansion and promote metastatic dissemination