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In different PH models, not only NLRP3 complex was widely observed in the inflammatory cells around the pulmonary vessels [119, 123], but also NLRP3, ASC, and Caspase-1 proteins were abnormally upregulated in PAECs and PASMCs [124, 125]

Anti-inflammatory interventions were statistically significantly more effective than placebo in reducing depressive scores for older adults with depression (SMD = 0.57, 95% CI = 0.98 to 0.15, p = 0.008)

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After the washing step that removes plasma and platelets, the cells may be suspended in a freezing solution