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Kaempferol induces apoptosis in HepG2 cells via activation of the endoplasmic reticulum stress pathway

Conduct regular safety assessments, including vital signs measurements and clinical evaluations, as appropriate

Promising therapeutic strategies include natural inhibitors (e.g., baicalin, silymarin, quercetin), pharmacological inhibitors like chlormethiazole, and gene-targeting approaches such as clustered regularly interspaced short palindromic repeat (CRISPR)-associated nuclease 9 (Cas9)-mediated knockdown in preclinical models [107, 110112]

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