Although the clinical correlates of the cellular pathology in bipolar disorder await better characterization, there is little doubt that documented pathohistological changes in key cortico-limbic areas and the white-matter tracts play an important role in the clinical manifestations of bipolar illness
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Recently, however, GR expression was detected in astrocytes of the adult SCN, suggesting that GC effects on the SCN may be more direct than previously thought 54
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