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This mechanistic separation is a central focus of publications in the field

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Environmental fluctuations, handling, transportation, and disease outbreaks are common stressors that disrupt homeostasis, impair immune responses, and increase disease susceptibility in fish

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Signs and symptoms The clinical presentation of HS can vary, but the characteristic signs are painful inflamed nodules, papules and pustules, double-ended pseudocomedones (blackheads) and cysts that merge together to form draining sinuses 4